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KMID : 0356919680010010001
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Korean Journal of Anesthesiology
1968 Volume.1 No. 1 p.1 ~ p.8
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Clinical Investigation of Methoryflurane
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郭一龍/Kwak, Il Yong
李相卨/Rhee, Sang Seol
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Abstract
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Methoxyflurane, a new anesthetic agent, was administered to one hundred surgical patients. The following are the results of clinical observation and liver function tests.
(1) Methoxyflurane is easily administered with a relatively simple vaporizer such as Heidbrink No.8 ether vaporizer in semi-closed system.
(2) Blood pressure, pulse rate and cardiac rhythm are remarkably stable if deep anesthesia is avoided.
(3) Excellent muscle relaxation is produced at intermediate levels of anesthesia without producing apnea. To avoid overdose it is recommended, however, to use muscle relaxants for operations which require highest degree of muscle relaxation such as upper abdominal procedures.
(4) Assisted respiration is advocated since methoxyflurane tends to depress respiration.
(5) Depth of anesthesia is easily controlled with growing experience so that overdose can a avoided.
(6) Analgesia extends into the recovery phase, minimizing the need for narcotics in the immediate postoperative period.
(7) Induction of and recovery from anesthesia is relatively prolonged. However, nausea, vomiting or delirium is less frequent than after ether anesthesia.
(8) Hepatotoxicity, as determined by bromsuiphalein, retention is of the same magnitude as that determined for diethyl ether.
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